The Brent Lab is developing and applying computational methods for mapping gene regulation networks, modeling them quantitatively, and synthesizing new network designs in living cells.
We are interested in understanding the influence of AMPK and PKA on gene expression and carbon fate.
We use a powerful combination of molecular and computational techniques to reconstruct the regulatory network that controls C. neoformans capsule synthesis - in order to target this process in antifungal therapy.
We are interested in the cellular mechanisms by which high sugar diets confer risk of Type 2 Diabetes.
The Brent Lab is developing the capability to design and build cellular differentiation systems that maintain mixed populations of cells in distinct, stable epigenetic states.