• Research Focus

    The Brent Lab is developing and applying computational methods for mapping gene regulation networks, modeling them quantitatively, and engineering new behaviors into them.

  • Mapping Transciption Factor Networks

    We develop efficient methods for determining which transcription factors can bind and regulate each gene in a genome.

  • Modeling Dynamic Transciption Factor Networks

    We develop efficient algorithms for predictive modeling of transcriptional profiles as a function of the activity levels of transcription factors.

  • Transcriptome Engineering

    We develop algorithms for designing modifications to a transcription factor network that will drive the cell into a transcriptional state associated with a desired behavior.

  • Understanding the relationship between binding and regulation

    We are working to understand why some genes that are bound by a transcription factor are functionally regulated by that factor while others are not.

  • Capsule Regulation and Virulence in Cryptococcus Neoformans

    We use a powerful combination of molecular and computational techniques to reconstruct the regulatory network that controls C. neoformans capsule synthesis - in order to target this process in antifungal therapy.